Jim, As per usual I am both impressed but also overwhelmed by your post. May I suggest one thing? I think you may be muddying your intellectual waters by confusing childhood hyperactivity with adult onset mania. I suggest that they have about as much in common as what used to be called Childhood Schizophrenia (now called Autism) and Adult Schizophrenia (CUT). You seem to have a lot of information on childhood disorders and I respect that but that which effects children,although impacting on adulthood, is not necessarily the same as that which effects adults I do see an evolutional component to both but the source of this impact is significantly different. I hope you take this suggestion in good faith,as intended, but please treat the two as seperate and distinct phenomena. For, they are...............Two brief and final thoughts. The word Manic is fromthe Greek Manik which means "inclined to madness". The word Mania is (diriv.) the anscient Roman Goddess of the Dead. The word Manic is the root of the word Germanic. Germanic means "of or pertaining to the Teutons. Teuton is defined as "a member of the Germanic people or tribes first mentioned in the fourth century B. C.". The Teutons were responsible for the German crusades of 1190 in the Holy Land whose members were known as "Manic Christians". Germanicus Caesar was a prominent Roman General (and son of Claudius Caesar) from 15 BC to 19 Ad (during the time of Christ). In order to take a truely evolutional perspective one has to be quite steeped in ancient history (et.al. "with a twist of ancient history").To take an historical perspective one has to follow the thread as far back as possible.Personally, I saw Darwin as an historian not a biologist ( or,if you will, a biohistorian). Once one starts follow the threads of human behavior one has to continue to go back a long, long, long very long time (ofcourse with the exception of mutations or permutations).....Take care........................Ed