CBT for Medication-resistant Depression

Fava, G. A., Savron, G., Grandi, S. & Rafanelli, C. (1997) Cognitive-behavioral management of drug-resistant major depressive disorder. Journal of Clinical Psychiatry, 58, 278-282.

ABSTRACT - Examined the application of cognitive-behavioral therapy to the treatment of drug-resistant major depression in 16 Ss (mean age 41.2 yrs) who failed to respond to at least 2 trials of antidepressant drugs. Ss displayed a significant decrease in scores on the Clinical Interview for Depression after therapy. 12 Ss were judged to be in remission at the end of the trial and only 1 of these patients was found to have relapsed at a 2 yr follow-up. Antidepressant drugs were discontinued in 8 of the 12 Ss who responded to cognitive-behavioral treatment. The authors conclude that these results suggest that a trial of cognitive-behavioral therapy by an experienced therapist should be performed before labeling an episode of major depression as "refractory" or "treatment resistant."

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