New developments regarding NIMH Treatment of Depression Collaborative Study

I wish to draw people's attention again to recent findings on the TDCRP data. Although CBT and IPT were grossly equivalent in outcomes, a finer-grained analysis showed that (1) IPT sessions contained a good bit of prototypical CBT, and (2) it was these aspects of the IPT sessions that showed the strongest associations with patient outcomes (reference below). This suggests that CBT components were more likely to have caused patient improvement in this study than non-CBT components. The study also points out that, even in a major RCT, we cannot presume that the label for a treatment is necessarily synonymous with what is actually going on in sessions. Hence, the importance of replication and meta-analysis.

Validity of controlled clinical trials of psychotherapy: findings from the NIMH Treatment of Depression Collaborative Research Program. Am J Psychiatry 2002 May;159(5):775-83 (ISSN: 0002-953X) Ablon JS; Jones EE Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA.

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More regarding NIMH Treatment of Depression Collaborative Study, by Jim Pretzer, 01/20/03

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